Work Strain Intensifies Inflammation in ACPA-Positive Rheumatoid Arthritis

New cohort data suggest physical job demands may worsen early joint inflammation in antibody-positive disease but effects ease with treatment.

Topline

Among people newly diagnosed with rheumatoid arthritis, higher work-related physical strain was linked to more severe joint inflammation at diagnosis only in those with anti-citrullinated protein antibodies. This association weakened after disease-modifying treatment began, highlighting an early window where mechanical stress may matter most.

Stud…