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Skip Antibiotic Prophylaxis for Cirrhosis GI Bleeds

New analysis suggests shorter or no antibiotic courses may be safe for patients with cirrhosis and upper gastrointestinal bleeding

Naveen Sankar S's avatar
Naveen Sankar S
Sep 07, 2025
∙ Paid
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A meta-analysis of 14 randomized controlled trials found that shorter antibiotic courses, or even no antibiotics, may not be worse than longer durations in preventing death among patients with cirrhosis and upper GI bleeding. The findings challenge long-standing international guidelines recommending up to a week of antibiotic prophylaxis.

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