Salicylate-Derived Drug SANA may Promote Weight Loss Through Creatine Thermogenesis
A first-in-class compound shows promise in activating fat-burning pathways independently of GLP-1 and UCP1
Topline
SANA, a nitroalkene derivative of salicylate, activates creatine-dependent thermogenesis in fat tissue, reduces insulin resistance, and promotes weight loss, with early-phase clinical trials showing good safety and tolerability.
Study Details
Obesity and metabolic syndrome continue to strain healthcare systems despite major advances like GLP-1 agon…
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