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Salicylate-Derived Drug SANA may Promote Weight Loss Through Creatine Thermogenesis

Salicylate-Derived Drug SANA may Promote Weight Loss Through Creatine Thermogenesis

A first-in-class compound shows promise in activating fat-burning pathways independently of GLP-1 and UCP1

Naveen Sankar S's avatar
Naveen Sankar S
Jun 19, 2025
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Salicylate-Derived Drug SANA may Promote Weight Loss Through Creatine Thermogenesis
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SANA, a nitroalkene derivative of salicylate, activates creatine-dependent thermogenesis in fat tissue, reduces insulin resistance, and promotes weight loss, with early-phase clinical trials showing good safety and tolerability.

Study Details

Obesity and metabolic syndrome continue to strain healthcare systems despite major advances like GLP-1 agon…

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