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Restoring the Brain’s Sugar Shield Could Protect Against Alzheimer’s and Aging Damage

New research shows repairing the blood-brain barrier may reverse cognitive decline in preclinical models

Naveen Sankar S's avatar
Naveen Sankar S
Aug 15, 2025
∙ Paid
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Scientists have identified age-related damage to the brain’s blood-brain barrier (BBB) caused by the breakdown of a protective sugar-rich layer called the glycocalyx.

In mice, restoring this “sugar shield” improved barrier function, reduced inflammation, and enhanced cognitive performance, offering a promising new approach to treating Alzheimer’s, Parki…

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