New Understanding of Colorectal Cancer Progression

Exploring How Ancient Viral Elements Drive Tumor Growth Through Oncogenic Signaling

Aug 01, 2024

∙ Paid

A detailed and scientific illustration of a colorectal cancer cell showing the role of endogenous retroviruses (ERVs) as enhancers in the gene regulatory network. The image should highlight the MAPK/AP1 signaling pathway activating the ERVs, which in turn regulate tumor-specific genes like ATG12 and XRCC4. The cancer cell should have a vibrant, complex interior with visible ERV elements activating gene expression. Include molecular and cellular elements to emphasize the scientific focus.

Topline:

Endogenous retroviruses (ERVs), remnants of ancient viral infections in our genome, have been found to play a critical role in the development and progression of colorectal cancer by acting as enhancers in cancer-specific regulatory networks, driven by oncogenic signaling pathways.

Study Details:

Recent research has revealed that ERVs, particularl…

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