New Lupus Guidelines Emphasize Hydroxychloroquine as the Cornerstone of Care

After 25 years, the American College of Rheumatology issues major updates highlighting treatment balance, shared decision-making, and steroid minimization.

The American College of Rheumatology (ACR) has released its first systemic lupus erythematosus (SLE) management guideline since 1999, reaffirming hydroxychloroquine (HCQ) as the backbone of therapy for most patients. The update calls for steroid tapering, individualized use of biologics, and greater patient engagement in treatment decisions.

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