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Menopause Marks a Critical Window for Sleep and Mood Care

Mood, sleep, cognition, and brain structure changes in midlife women.

Naveen Sankar S's avatar
Naveen Sankar S
Jan 28, 2026
∙ Paid

In a UK Biobank analysis of about 125,000 women, menopause was associated with higher self-reported anxiety, depression, and sleep problems, alongside smaller gray matter volumes in memory and emotion-related regions. Women who reported using hormone replacement therapy (HRT) had, on average, higher baseline mental health symptoms and the lowest measure…

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