Ketogenic Diet for Treatment Resistant Depression Shows Modest Short Term Benefit

A randomized clinical trial suggests small early improvements in severe depression, with uncertain durability and clinical impact.

In adults with treatment-resistant depression, a ketogenic diet added to usual antidepressant therapy led to a modest improvement in depression scores at 6 weeks, but the benefit was not sustained at 12 weeks and required intensive dietary support.

Study Details

A randomized clinical trial published in JAMA Psychiatry evaluated whether a ketogenic diet co…