Isotretinoin in Acne Patients Signals Broader Mental Health Concerns

New analysis of FDA reports suggests mood disorders, self-injury, and psychosis may also need monitoring during treatment

Mar 25, 2025

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A modern and professional medical illustration representing the mental health monitoring of acne patients undergoing isotretinoin treatment. The scene includes a clean, warm-toned background with soft oranges, pinks, and light neutrals to convey positivity and calm. A simplified human face or silhouette is shown with stylized glowing icons representing mood, anxiety, and mental clarity—such as a glowing brain, mood faces, or neurons. A side view of the face has acne marked lightly and abstract symbols representing medication and monitoring. The design is clean, clear, and approachable, with a focus on safety, support, and innovation. No text or labels are present.

Topline:

A 20-year analysis of FDA adverse event reports found isotretinoin users, especially those treated for acne, showed increased odds of psychiatric issues beyond depression and suicide—including anxiety, mood changes, and psychosis—warranting closer mental health monitoring during early treatment.

Study Details

Isotretinoin, a powerful acne treatmen…

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