Higher Klotho Levels May Protect Aging Brains

New evidence links a longevity protein to preserved thinking skills despite brain shrinkage in adults at risk for Alzheimer disease.

In adults at higher genetic risk for Alzheimer disease, higher blood levels of the longevity protein klotho were associated with better cognitive performance even when brain imaging showed more age-related atrophy, with the effect strongest in older individuals.

Study Details

Age-related brain atrophy is a well-known marker of cognitive decline and Alzhei…