Antidepressants and Beta Blockers Increase Risk for Bradycardia and Low Blood Pressure

New evidence shows interactions between antidepressants and beta blockers may amplify side effects, urging careful monitoring and alternative prescribing strategies.

A new analysis presented at HYP 2025 found that combining certain antidepressants (SSRIs, SNRIs, bupropion, duloxetine) with CYP2D6-metabolized beta blockers significantly increases drug exposure, lowers systolic blood pressure by up to 20%, and raises bradycardia risk by 25%.

Study Details

Depression and hypertension often coexist, making the concurrent …