Alzheimer’s Risk May Be Driven by a Single Gene

New population-scale data suggest APOE variants account for most Alzheimer’s cases, reshaping how genetic risk is understood

Large-scale genetic and clinical data suggest that common variants of the APOE gene may account for the majority of Alzheimer’s disease cases and nearly half of all dementia, challenging the long-held assumption that only APOE4 meaningfully drives risk.

Study Details

Alzheimer’s disease remains one of the most complex and costly neurodegenerative disorder…